| Pair Name | Artesunate, TP-0903 | ||
| Phytochemical Name | Artesunate (PubChem CID: 6917864 ) | ||
| Anticancer drug Name | TP-0903 (PubChem CID: 56839178 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Artesunate, TP-0903 | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->DNA damage and cell death | |||
| Gene Regulation | Down-regulation | Expression | ZEB1 | hsa6935 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Activity | CDH3 | hsa1001 | |
| Up-regulation | Phosphorylation | H2AX | hsa3014 | |
| Down-regulation | Expression | SOD2 | hsa6648 | |
| Down-regulation | Expression | GPX8 | hsa493869 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| T-47D | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0553 | |
| ZR-75-1 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0588 | |
| SK-BR-3 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0033 | |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| MDA-MB-436 | Invasive breast carcinoma | Homo sapiens (Human) | CVCL_0623 | |
| BT-549 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_1092 | |
| HBL-100 | Healthy | Homo sapiens (Human) | CVCL_4362 | |
| MCF-10A | Healthy | Homo sapiens (Human) | CVCL_0598 | |
| Result | Synergistic interactions between TP-0903 and ART indicate that combination approaches involving these compounds can have therapeutic prospects for TNBC treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Mesenchymal-epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate. Sci Rep. 2024 Jan 3;14(1):425. doi: 10.1038/s41598-023-50710-3. | Click |
